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HS Code |
418367 |
| Cas Number | 81-13-0 |
| Iupac Name | ((R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide) |
| Molecular Formula | C9H19NO4 |
| Molar Mass | 205.25 g/mol |
| Appearance | Colorless to slightly yellow, viscous liquid |
| Odor | Mild, characteristic odor |
| Solubility In Water | Freely soluble |
| Melting Point | 64-68 °C (crystalline form) |
| Ph Value | 5.0-7.0 (5% solution) |
| Optical Rotation | [α]D20 = +29.0° to +32.0° (in water) |
| Stability | Stable under recommended storage conditions |
| Synonyms | Dexpanthenol, Provitamin B5 |
As an accredited D-Panthenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | D-Panthenol is packaged in a sealed 25 kg blue plastic drum with a secure lid, labeled with product information. |
| Container Loading (20′ FCL) | D-Panthenol 20′ FCL: 10kg/drum, 80 drums per container, net weight 800kg, securely packed for international chemical transport. |
| Shipping | D-Panthenol should be shipped in tightly sealed, original containers to protect it from moisture, light, and heat. Store and transport at controlled room temperature. Ensure containers are clearly labeled, upright, and comply with relevant regulations. Avoid exposure to incompatible substances. Handle with standard precautionary measures to prevent leaks and contamination during shipping. |
| Storage | D-Panthenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight and moisture. Keep it at temperatures below 25°C. Avoid exposure to strong oxidizing agents and acids. Store separately from incompatible substances, and ensure the storage area is clearly labeled and restricted to authorized personnel. |
| Shelf Life | D-Panthenol typically has a shelf life of 24 months when stored in tightly sealed containers, protected from light and moisture. |
Applications of D-Panthenol in Industrial ManufacturingD-Panthenol serves as a specialty raw material for targeted application sectors, offering well-defined functions in formulations requiring moisturizing, conditioning, or wound-healing properties. Below, we detail specific industrial use cases, process requirements, and compliance standards for key downstream industries. 1. Skin Care and Personal Care FormulationMajor skincare brands and contract manufacturers use this raw material as an active moisturizing and skin-conditioning agent in facial creams, body lotions, and after-sun products. Its pro-vitamin B5 function helps support the skin barrier and improves sensation of hydration in clinical trials and real-world user tests. It requires strict compliance with international cosmetic and pharmaceutical ingredient regulations for safe use in leave-on and rinse-off products. D-Panthenol must be carefully solubilized in the aqueous phase before emulsion formation, and heat- and pH-stability checks must follow in QC protocols. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
2. Hair Care and Hair Treatment ProductsLeading hair care producers use D-Panthenol as a conditioning, humectant, and strengthening additive in shampoos, conditioners, leave-in sprays, and intensive hair masks. Its molecular structure provides support for cuticle penetration and enhances fiber elasticity. The ingredient typically enters batching tanks after dissolution, with controlled temperatures to avoid degradation. Finished goods undergo compatibility trials and stability testing in accordance to regional norms for rinse-off and leave-on hair applications. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Pharmaceutical Topical and Wound Care ApplicationsIn regulated pharmaceutical production, D-Panthenol acts as a key ingredient in wound-healing ointments, burn gels, and mucosal sprays. Its use qualifies under pharmaceutical-grade purity, demanding batch-specific documentation and full traceability. Manufacturers adhere to stringent production guides such as cGMP and regional pharmacopeial monographs, with the substance added in pre-solubilized form at measured cooling stages to prevent loss of functional properties. Release testing includes assay, heavy metal content, and microbial limits. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Veterinary Care and Animal Hygiene PreparationsVeterinary pharmaceutical firms and pet care suppliers utilize D-Panthenol to promote epidermal repair and improve moisture levels in topical ointments and sprays for companion animals. Integrators source material from audited GMP factories, ensuring animal-use ingredient declarations and cross-referencing relevant veterinary compendia. Processing demands meticulous temperature control and avoidance of pyrogenic contamination as raw material is blended with traditional veterinary excipients in pre-specified ratios. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
5. Functional Food and Beverage FortificationFood technologists and beverage formulators employ D-Panthenol as a provitamin B5 source in nutritional drinks and enriched solid foods, observing food additive and novel foods regulations for safety and labeling. Strict control governs raw material purity and allergen status, and processing requires incorporation during liquid blending or pre-mix solutions to ensure homogeneous distribution. Online sensors check dosing accuracy and product stability through shelf-life testing, especially in ready-to-drink and dry blend applications. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
6. Oral Hygiene and Dental Care ProductsMajor oral care manufacturers formulate D-Panthenol into toothpaste, mouthwash, and oral gels intended for mucosa soothing and moisture retention. Ingredient intake abides by internationally harmonized cosmetic and medical device ingredient lists, with batch controls for allergenicity and absence of sensitizing byproducts. Material gets blended during late aqueous stage of toothpaste manufacturing to secure uniformity before tube filling, and cold-processing is used to minimize loss of activity in mouth rinses. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
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Years of manufacturing D-Panthenol have given our team a front-row view of how this ingredient shapes modern cosmetics, pharmaceuticals, and a host of personal care products. We take a hands-on approach, overseeing every step from raw material sourcing to finished product packaging. This focus carries through in the chemistry, physical handling, and daily problem-solving around our reactors. D-Panthenol, which you might also recognize as Pro-Vitamin B5, earns its keep with reliability and quality, and it always passes muster in the demanding eyes of customers and regulators.
Our D-Panthenol comes as a transparent, viscous liquid. Each batch contains at least 98% pure pantothenol. Years of steady production and scale-up make it possible for us to promise narrow purity ranges and a homogenous product. Quality is measured for more than just purity; we track water content, specific optical rotation, and hydrolysis levels to ensure what leaves the plant matches the strict pharmaceutical and cosmetic standards embraced worldwide. Simple numbers—the refractive index, the assay—often mean the difference between an excellent batch and something that stays in the lab.
Each stage of our process has been revised and refined for over a decade, but the fundamentals stay the same. We start with clean, food-grade raw materials. Carefully controlled reactions help us avoid unwanted byproducts, so we achieve high yield and save on purification steps. Routine in-line monitoring tells us instantly when the reaction veers off track, and technicians intervene before wastes accumulate. It can be tempting to automate everything, but nothing substitutes for the eyes and experience of our senior operators. Over the years, a few tweaks—adjusted temperatures at a particular step or longer dwell times—make for a more forgiving process.
Once the chemical synthesis finishes, filtration removes trace byproducts. We then run the solution through vacuum distillation. Each stage of vacuum distillation changes the composition a little, guided by ongoing testing. We’re meticulous at this stage, keenly aware that contaminants, even in very low amounts, might trigger skin irritation later or mess up the clarity in high-end formulations. Before a batch even reaches our bottling system, it passes through final refining to reach our requirements.
D-Panthenol helps creams, shampoos, and serums deliver much more than marketing claims. In our collaborations with leading brands, we track not just chemical purity but also how the ingredient feels under the hands of formulators. Cosmetic companies pay close attention to clarity and absence of off-odors—the wrong impurity profile leads to a sticky texture or a yellow tint that stands out on shelves lined with clear serums. So, beyond meeting the global compendial standards, we push for a product that works as cleanly in the lab as it does at scale.
Pharmaceutical partners focus on D-Panthenol’s consistency dose to dose, especially the strong batch-to-batch reproducibility. Many wound-healing and topical products require the ingredient to stay stable even under changing temperatures, with no unexpected pH drift. Our internal auditing team spends as much time sampling end products as measuring in-line results. This feedback loop, between what our clients want and what our systems can deliver, shapes every round of process improvement.
If a developer runs into issues while using D-Panthenol, like difficulty dissolving it into high-glycerin bases or questions about compatibility with specific preservatives, we don’t just quote specs. The doors to our labs stay open whenever troubleshooting calls come in. Our chemists often review finished product analyses, hunt for interactions, and in many cases, help tweak process parameters at the customer’s end. This partnership, fueled by open data sharing and repeated conversations, builds trust far beyond the sale.
This ingredient brings real function to the skin and hair care market. In skin creams and lotions, D-Panthenol gets absorbed, converting to pantothenic acid once inside the epidermis. Here, it plays a supporting role in soothing irritated or inflamed skin; direct user feedback often mentions improvement in scaliness and redness. Dermatology teams who schedule in-person patch testing see D-Panthenol at the top of recommendations for sensitive-skin formulations.
Hair care is another major area. Shampoos, conditioners, and sprays use this ingredient for moisture retention, shine, and combability. Product developers in major global brands reach for D-Panthenol when their R&D briefs call for fortifying split or fragile hair. In the shower or on the shelf, this ingredient supports claims of better texture, manageability, and less breakage. Our batches consistently maintain ease of incorporation, with no undissolved residues.
Pharmaceutical applications require tight process control and documentation. Burn creams, post-surgical ointments, and drops for minor oral ulcers feature D-Panthenol for its calming, moisture-binding qualities. Clinics valuing traceability and pharma-grade sterility often request certificates detailing every check, from starting raw materials down to microbiological screenings. We track each lot through our ERP systems, so when a hospital requests product data, we can provide everything from batch origin to test results.
Real-world scenarios shape every manufacturing choice. Sometimes buyers mention trouble in sourcing D-Panthenol that dissolves completely at lower temperatures. In these cases, we review the molecular profiles for residue issues and suggest optimal solution conditions based on years of handling these exact complications. Rather than selling a stock answer, we share lab test results focused on their target formulations. For customers exporting final products, especially those facing differences in market regulations, we provide documentary support and tailor the refining process to meet divergent global standards without sacrificing core purity.
Handling shelf-life questions, our technical staff draws from both storage simulations and the less glamorous job of tracking retained samples for real-world signs of degradation. While regulations often demand set expiration windows, our retained sample library—spanning years—gives us confidence in stability claims. If we find a problem, such as marginal yellowing after extended exposure to air, we feed that insight back to our process engineers and adjust future batches.
Regulatory oversight touches every aspect of our operation. Compliance teams stay updated on evolving REACH and FDA guidelines. Rather than treat compliance as a checklist, we use each audit or notice as a learning event. It’s not just about getting a stamp of approval for sale—years of supplying to multinational firms taught us the value of preemptively catching trends in allowable impurity levels, labeling standards, and country-of-origin claims.
We know how important transparency and traceability can be in an age where recalls or ingredient issues travel with speed across global markets. Each batch produced carries a full documentation chain: time-stamped logs, in-process sampling sheets, purity certificates, and post-shipment feedback from recurring clients. For larger buyers who audit our facility or require on-site batch verification, we open our logs and batch registers, sharing insights on how production parameters affect end-use.
D-Panthenol stands apart from its mirror-image sibling, L-Panthenol, and from the racemic DL-Panthenol. Many buyers ask about the difference. Only D-Panthenol demonstrates biological activity in humans by seamlessly converting to pantothenic acid in the body. The other forms linger without supporting skin or hair cell regeneration; pharmaceutical and cosmetic standards almost exclusively reference D-Panthenol for this reason. In cases where cost reduction pushes interest toward DL-mixed forms, candid discussions about efficacy and sensory impact guide those buyers back to the D-enantiomer—no matter how tempting a lower price tag might seem.
Some sourcing teams new to the market ask if powdered versions offer better stability or solubility. From our track record, powdered D-Panthenol, although easier to transport and store in some contexts, introduces its own handling issues. The liquid version dissolves instantly, integrates more smoothly for process engineers, and requires less time for product reworking. When partners seek maximum convenience and shortest path to production-line scale-up, the liquid stands out.
As a manufacturer, we touch D-Panthenol every day. Our shift teams spot the visual cues: the subtle differences in viscosity on humid days, the way color holds up under harsh warehouse lighting, and the exact rate it runs down a clean glass surface. In so many pilot plant scenarios, an unexpected shift in ambient temperature or air pressure will show itself first in a change to this product’s behavior. By controlling these details—tight lids, targeted humidity control, chilled storage where the climate swings—we deliver product that matches spec well beyond normal tolerance ranges.
Lab techs and process engineers also give feedback. They care about pumping speed at scale, ease of filtering before addition to reactors, and resistance to gumming up automated filling lines. No brochure or spec sheet can replace the reliability of a product that survives five cleans and breakdowns in a packaging hall without clumping or losing its strength.
Direct feedback leads us to schedule frequent production reviews, where plant workers share observations about raw material changes, filter performance, or foaming behavior during mixing. Sometimes, a shared observation—foaminess due to trace surfactants, flash in viscosity due to ambient heat—prompts an equipment change or a subtle raw material tweak in the next order cycle. These incremental improvements protect our process and the products our buyers end up making.
Markets rarely cooperate, and D-Panthenol faces its share of supply swings. In busy periods, like the surge in hand sanitizer and skin care demand during pandemic responses, raw material markets get tight. On the factory side, we buffer stock and ramp up capacity in advance of such waves, but we also learn the reality: proximity to raw material supplies, local weather-driven production downtime, and shifting regulatory controls sometimes restrict output. These forces drive us to maintain strong contacts with upstream suppliers and continually invest in redundancy, from spare pumps to alternate logistics partners.
Logistics mean more than just fast trucks and secure drums. Changing hazardous material rules, dockside delays, or new customs paperwork for cross-border shipments can threaten on-time supply. Our logistics team double-checks each waybill, working directly with freight operators when loads shift or schedules break. On one occasion, a late-winter freeze forced rerouting and temporary warehousing of a critical international shipment; close communication with our receiving customer smoothed the process, and knowing their production line was waiting, we pushed for updates day and night. Staying responsive—offering real-world solutions as obstacles appear—means customers keep their trust and return year after year.
We see D-Panthenol’s impact not just in shipped drums, but in the finished creams, lotions, sprays, and ointments lining store shelves or distributed to clinics. Each order carries a piece of our plant’s focus on reliability, safety, and honest service. Expert handling of customer queries, whether on allergen declarations or on-the-spot formulation support, sets apart experienced suppliers from anonymous bulk sources. We know that every drum, no matter where it ends up, carries our reputation as a manufacturer who stands behind the product.
From the inside looking out, D-Panthenol’s popularity stems from a reliability earned through consistent process management, openness with partners, and attention to customer feedback. Rather than offering generic product details, we take pride in giving a transparent account of what happens, every time, between raw materials coming in and finished product going to market. This clear, proven connection—between our factory and the solutions our customers deliver—drives us to refine every batch, knowing the difference that trace purity, consistent texture, and open support makes for everyone using D-Panthenol in their work and daily lives.
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