Products

4-Methoxyphenol

    • Product Name: 4-Methoxyphenol
    • Chemical Name (IUPAC): 4-methoxyphenol
    • CAS No.: 150-76-5
    • Chemical Formula: C7H8O2
    • Form/Physical State: Solid
    • Factroy Site: No. 1 Xuelin Street, Haining, Zhejiang, China
    • Price Inquiry: sales7@bouling-chem.com
    • Manufacturer: Jiangxi Brother Pharmaceutical Co., Ltd.
    • CONTACT NOW
    Specifications

    HS Code

    732954

    Chemical Name 4-Methoxyphenol
    Synonyms Hydroquinone monomethyl ether, Mequinol, p-Methoxyphenol
    Molecular Formula C7H8O2
    Molar Mass 124.14 g/mol
    Cas Number 150-76-5
    Appearance White to pale pink crystalline solid
    Melting Point 54-57 °C
    Boiling Point 243 °C
    Density 1.12 g/cm³
    Solubility In Water 11 g/L at 25 °C

    As an accredited 4-Methoxyphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 4-Methoxyphenol is supplied in a sealed amber glass bottle with a screw cap and hazard labeling for laboratory use.
    Container Loading (20′ FCL) Container loading (20′ FCL) for 4-Methoxyphenol involves safely packing drums or bags, ensuring secure, hazard-compliant international chemical transit.
    Shipping **Shipping for 4-Methoxyphenol:** 4-Methoxyphenol is typically shipped in sealed, chemical-resistant containers to prevent contamination and moisture absorption. It should be handled as a hazardous material, conforming to local and international transport regulations. Packages must be clearly labeled, protected from physical damage, and stored away from sources of ignition or incompatible substances during transit.
    Storage 4-Methoxyphenol should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Store it in a tightly closed container made of compatible material to prevent contamination and moisture absorption. Label the container clearly, and ensure appropriate safety measures are followed to minimize exposure and chemical degradation.
    Shelf Life 4-Methoxyphenol typically has a shelf life of about 2 years when stored in a cool, dry, and tightly sealed container.
    Application of 4-Methoxyphenol

    Applications of 4-Methoxyphenol in Industrial Manufacturing

    As a specialized manufacturer, we support industrial users with consistent-quality 4-Methoxyphenol tailored for well-established chemical manufacturing sectors. We focus on real-world downstream applications where this raw material delivers precise performance and safety based on industry standards. The following scenarios detail how our material integrates into advanced formulations and production lines across key markets.

    1. Polymerization Inhibitor in Monomer and Resin Manufacturing

    The phenolic structure of 4-Methoxyphenol suppresses unwanted polymerization in unsaturated monomer storage and transportation, extending product shelf life and supporting safe processing. Manufacturers dose this inhibitor during bulk monomer synthesis, blending, and logistics, where reactive vinyl and acrylate monomers would otherwise prematurely polymerize, causing blockages and product degradation. Stable inhibitor performance is essential in continuous and batch operations, especially for high-purity monomers used in polymer and resin systems for coatings and adhesives.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Regulation (EC) No. 1907/2006 for chemical control
    • ASTM D1437 for inhibitor content in monomers
    • OSHA 29 CFR 1910.1200 (Hazard Communication) for workplace handling

    Typical usage ratio

    • 50–250 ppm based on monomer type; higher for acrylates (up to 250 ppm), lower for styrene and MMA (typically 50–150 ppm), with dosage adjusted according to storage duration, temperature, and monomer reactivity.

    Downstream process integration

    • Added during monomer purification and blending prior to packaging or transfer to resin reactors, using controlled dosing systems.
    • Monitoring conducted via HPLC or GC for active content verification before and after inhibitor addition.

    Final product types

    • Bulk acrylic and methacrylic monomers (MMA, BA, EHA)
    • Styrene monomer
    • Unsaturated polyester resins for composites
    • Adhesives and specialty coatings base formulas

    2. Intermediate for Synthesis of Pharmaceuticals

    Major pharmaceutical companies and CDMO operators use 4-Methoxyphenol as a controlled intermediate during multi-step synthesis of active ingredients, including certain anesthetics, local analgesics, and anti-arrhythmic drugs. Strict quality control and traceability govern its use, requiring validated process controls to ensure purity and regulatory compliance throughout the API (active pharmaceutical ingredient) value chain.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • 21 CFR Part 210/211 (US cGMP)
    • USP–NF and EP monographs for specific APIs involving 4-Methoxyphenol intermediates
    • FDA DMF (Drug Master File) referencing for raw material sourcing

    Typical usage ratio

    • Stoichiometric ratios determined by route of synthesis; typically, 4-Methoxyphenol is charged at 0.8–1.2 molar equivalents to limiting reagents in the intermediate-forming step, with optimization based on yield and impurity controls.

    Downstream process integration

    • Introduced in N-alkylation, etherification, or acylation reactions inside GMP-compliant API plants.
    • Batch QC via HPLC for residual phenol content and tracking of transformation to downstream intermediates.

    Final product types

    • Pharmaceutical finished dosage forms (oral anesthetics, antiarrhythmic tablets)
    • API precursors for key small-molecule drugs
    • Paracetamol intermediate routes in select generic markets
    • Bulk pharmaceutical intermediates for global B2B supply

    3. Stabilizer in Agrochemical Formulations

    4-Methoxyphenol prevents oxidative degradation of active ingredients in specific crop protection chemistries, such as phenoxy herbicides and certain insecticides. Formulators use it to maintain product potency during storage and logistical transport in harsh environments. Its effectiveness depends on compatibility with emulsifiers, solvents, and active agents—addressed through careful formulation trials and analytical validation.

    Industry compliance standards

    • FAO/WHO Specifications for agricultural pesticides
    • ISO 23195 for agrochemical formulation quality
    • China GB 2763 (MRL standards for pesticides)
    • EPA PR Notice 2012-1 (stabilizer disclosure for crop protection products)

    Typical usage ratio

    • 0.02–0.1% by total formulation mass; rates determined by actives’ oxidation sensitivity, storage targets, and regulatory exposure limits.

    Downstream process integration

    • Added in the pre-blending stage before emulsification or solvent dilution of concentrate products.
    • Homogeneity verified by GC-MS and accelerated shelf-life testing under simulated transport conditions.

    Final product types

    • Selective and non-selective herbicide concentrates
    • Insecticide emulsifiable concentrates (ECs)
    • Bulk agrochemical technicals for downstream toll formulating
    • Ready-to-use crop protection mixtures for B2B supply

    4. Antioxidant in Industrial Lubricants and Hydraulic Fluids

    Lubricant compounders utilize 4-Methoxyphenol to slow oil oxidation, particularly in mineral and synthetic base oils where long-term stability is critical. By quenching peroxides and free radicals, the additive extends lubricant operating life, lowers sludge formation, and maintains viscosity performance during heavy-duty industrial operations. Used in critical assets including compressors, gearboxes, and hydraulic systems, the additive must also meet approval for non-catalyst poisoning and compatibility with commonly used base stocks.

    Industry compliance standards

    • DIN 51524 for hydraulic oils
    • ASTM D943 (TOST) and D2272 (RBOT) for oxidation stability
    • API 614 standard for systems with stringent lube requirements
    • OEM approvals where required for base stock compatibility

    Typical usage ratio

    • 50–300 ppm, optimized based on base oil oxidative vulnerability and presence of synergistic additives such as amines and diphenylamines.

    Downstream process integration

    • Incorporated in blending kettles during final additive package introduction, under nitrogen blanket to prevent pre-mature oxidation.
    • Batch sampling follows for baseline oxidation number and aging simulation testing.

    Final product types

    • Industrial turbine and compressor oils
    • Hydraulic fluids (HLP, HVLP types)
    • Automotive and heavy-duty gear lubricants
    • High-performance greases for OEM applications

    5. Inhibitor in Cosmetic and Personal Care Ingredient Production

    4-Methoxyphenol is applied at key points in the synthesis and stabilization of cosmetic-grade aromatic ingredients, preventing auto-oxidation and color drift in sensitive compounds such as hydroquinone ethers and fragrance bases. Cosmetic ingredient manufacturers select this stabilizer where color and shelf-life properties are critical to downstream brand claims. The additive’s cosmetic use is strictly controlled under relevant chemical and safety management frameworks, with batch traceability.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • IFRA Standards for aromatic ingredient safety
    • China Cosmetic Supervision and Administration Regulation (CSAR)
    • ISO 22716 (Cosmetic GMP) for production sites

    Typical usage ratio

    • 0.01–0.05% in concentrated aromatic intermediates; level refined based on light color retention and odor compatibility in pilot batches.

    Downstream process integration

    • Integrated in the final synthesis or purification step of fragrance precursor production before dilution to commercial strength.
    • QC through spectrophotometric/colorimetric analysis and storage stability acceleration protocols.

    Final product types

    • Fragrance intermediate concentrates
    • Stabilized hydroquinone-based cosmetic actives
    • Color-stable personal care ingredient batches
    • Bulk aromatic raw materials for further formulation

    Free Quote

    Competitive 4-Methoxyphenol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please contact us at +8615371019725 or mail to sales7@bouling-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: sales7@bouling-chem.com

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    Certification & Compliance
    More Introduction

    4-Methoxyphenol: Practical Insight from the Manufacturing Floor

    Meeting Industry Demands with Reliable Consistency

    Every year, our team at the plant works through tons of raw materials and reacts them under strict conditions, and 4-Methoxyphenol (often known as MEHQ or hydroquinone monomethyl ether) runs as one of our mainstays. Operating reactors, cleaning up the lines, and seeing raw phenol enter and leave as a pure bright white crystalline powder at the end of the process means seeing firsthand how clean chemistry has to be. We’ve found MEHQ particularly convincing for its value in so many niches: stabilizer work, intermediates for syntheses, antioxidants, and polymer inhibitors. Producing it ourselves, we have full control over every stage—no surprises in quality from batch to batch—which is important for our long-term customers who manufacture things like resins, acrylates, and pharmaceuticals.

    Refined Through Years of Hands-On Production

    On our production lines, we’ve dialed in conditions that coax optimal yield from high-purity hydroquinone and methylating agents. No two runs are exactly the same—ambient conditions, minor variances in feedstock, and skill at the process table each play a role. We install in-line gas chromatography and HPLC to track every fraction of impurity; you learn quickly how even small shifts in process temperature or solvent ratios can show up as downstream issues for customers making precision polymer products or pharma intermediates. Our standard batch comes out at a purity above 99.5% (HPLC), melting in the 54–57°C range, with moisture tightly controlled below 0.1%. That makes it work efficiently as a stabilizer, especially in monomer storage and transport, where lesser grades cause yellowing or gel formation.

    What Users See: Storage and Performance Beyond the Drum

    Direct feedback from our customers tells us exactly what matters. Polymer producers and acrylate suppliers rely on MEHQ’s antioxidant ability to delay spontaneous polymerization. You want to keep storage drums of acrylates from gelling—nothing’s more irritating than receiving a drum with solidified product because the stabilizer ran short or degraded from a high impurity load. MEHQ, especially at high purity, brings a predictable inhibition effect, so shipments reach their destination in pourable condition. Our own warehousing tests mimic true seasonal ranges. Nothing like having to drag in frozen drums in mid-winter or try to ensure inhibition holds up through a high-heat summer transport across the continent. Careful drying, double bagging, and robust metal drums keep the material free from excess moisture—a critical point, since some competitors skip these steps, leading to inconsistent product.

    The True Value of Manufacturing at Source

    A lot of players list MEHQ as available, but unless you’re running the reactors daily, certain details slip by. There’s more to this intermediate than a chemical structure. We invest in fresh batches year-round. Residual solvents, color formation, and dust-handling are all under our control. From the first lot down a new purification column, we monitor each output, documenting data on purity, melting range, and solubility across many solvents. These are shared openly with long-term customers who sometimes use specialty solvents or blend the product in conditions that highlight even minor differences.

    If there’s a spike in residual methyl chloride, you’ll spot it as an odd haziness during downstream reaction work. We tweak our extraction and drying steps so these issues don’t travel into the next plant’s process—a difference that comes from in-house production and skilled operators keeping an eye on more than just the big numbers.

    Usage Across the Spectrum

    From an end-user perspective, this product’s value lies in its broad scope. If your plant produces acrylic acid or its esters, MEHQ stabilizes the monomer in tanks and tankers, holding off runaway reactions. Our partners feeding pilot reactors for UV-curable resins often dose MEHQ at ppm levels, finding its behavior superior to other phenolic inhibitors especially in hot, humid conditions.

    We also supply direct to pharma intermediate manufacturers. Nowhere do purity and trace metal content matter more than here. Variability in commercial batches brings regulatory headaches, batch rejection, or more urgent: product recall. By holding to medical-grade limits of organic and inorganic impurities, and retaining careful QC documentation, we help pharmaceutical clients pass audits—without requiring endless retesting or costly reprocessing.

    In the photographic and dye sectors, MEHQ’s role as a developer or inhibitor sits less prominently nowadays, but some specialist users rely on particular solubility and melt characteristics. Reproducible results here rely on our thorough approach on the plant floor: filtration, slow crystallization, thermal drying, and precise packaging.

    Differentiation: MEHQ and Its Close Relatives

    Some folks ask about the differences between MEHQ and other popular stabilizers. Hydroquinone and MEHQ share some overlap, but 4-Methoxyphenol resists oxidation better in open systems and has improved solubility in esters and certain nonpolar monomers. Hydroquinone fits applications with simple storage, but MEHQ holds up under tougher atmospheric or temperature swings. Some polymer systems benefit directly from the methyl ether function, showing less color pick-up and improved reactivity profiles in UV-cure conditions.

    Other inhibitors, such as BHT (butylated hydroxytoluene) or PTZ (phenothiazine), target different niches. BHT works as a general food-grade antioxidant but falls short for high-reactivity monomers, and PTZ brings different solubility and reactivity traits. MEHQ’s moderate volatility and easy handling—neither stubbornly sticky nor abrasive—suit automated lines, filling machines, and closed feed systems especially well.

    Solving Challenges: Supply Chain, Safety, and Regulatory Trends

    On the practical side, reliable MEHQ supply ensures stability in our customers’ processes, not just in their products. Delays or changes in quality can stop production lines, trigger product downgrades, or lead to expensive disposal of out-of-spec monomer lots. Producing MEHQ on our own terms, with modular lines and backup reactors, reduces risk of shortage, especially during market swings or supply chain disruptions. As regulatory authorities worldwide raise the bar for contaminant control, especially residual solvents and trace metals, we respond by adding in-process analytics, updating air filtration, and keeping ahead of REACH, TSCA, and pharmacopeial standards.

    Beyond compliance, plant safety has always held our focus. MEHQ’s toxicological and ecological profile drives our design choices—dust control, fume management, bulk container lining, and operator training. Every plant incident delivers lessons. Runaway reactions from improper stabilizer levels or airborne dust accumulation risk business interruption and health impacts, so we maintain hazard review teams and run small-scale mock-ups before any process change. Waste handling procedures cut emissions and protect our team and the communities around the plant.

    Technical Support and Integration

    We ship more than product in drums. End-users sometimes face obscure compatibility puzzles. Is this batch showing reduced action? Does it dissolve fully in a proprietary monomer blend at scale? Our technical crew walks clients through bench tests and, if needed, tweaks purification and packaging for special runs. We pull production data—melting point curves, spectral analysis, moisture reports—so external labs don’t waste time troubleshooting issues we solved upstream. Word spreads among buyer engineers: if you need a batch that matches last year’s spec down to trace impurity profile, we check our internal archive before the first drum leaves the warehouse.

    Scale-up support takes center stage for newer clients launching or reformulating polymer and resin lines. Advice on dosing, dissolution speed, and compatibility with other stabilizers comes direct from operators who have handled every formulation, not just sales staff reading from data sheets. That real-world experience keeps projects on track and builds decades-long customer relationships.

    Innovating Toward Lower Environmental Footprint

    MEHQ’s legacy in chemical manufacturing dates back nearly a century, yet the drive for cleaner, greener methods keeps our process engineers busy. We invest in recovery of solvents, heat integration, and process water treatment to minimize both waste and energy use. Every improvement filters into lower carbon footprint per ton—vital as downstream partners face increasing scrutiny from regulators and their own customers. We share lifecycle analysis data for key markets, showing marked reduction since adding solvent recovery loops and switching to renewable energy for core process steps.

    We’re developing new crystallization and filtration approaches designed for reduced chemical use and greater purity. Some partners ask for custom low-residue grades— for next-generation electronics, optoelectronics, or advanced coatings—giving us the motivation to keep refining old steps. Trials on continuous processing instead of single-batch runs stand to improve both productivity and environmental profile.

    Main Takeaways from Manufacturing Experience

    Producing 4-Methoxyphenol teaches lessons at scale and in detail. Not all powder is created equal. Real-world quality control—hands-on monitoring for purity, consistency, and fast response to outlier test results—ensures that our customers, from resin producers to pharma specialists, build on a solid chemical foundation. As regulations tighten and customers push for reliability, long-term stability, and safety data, our in-house batch records and investment in continuously improved processes have set a high standard few traders or repackagers can match.

    In the next few years, downstream requirements will keep tightening. Real value stems from knowing your raw material supply—not just by grade and spec sheet, but by honest plant-floor reliability. End-users can only build trust on a transparent trail of evidence, best backed up by steady chemistry and open dialogue from the manufacturer’s side. That remains a core part of our approach: keep the chemistry clean, the records open, and the lines of communication fully active from vessel to drum to end product.